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Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry
Eight mice, harbouring orthotopic tumours of the 3LL ΔNRAS cell line, were treated for 7 days with the KRAS G12C inhibitor MRTX1257 (n = 3) or vehicle (n = 5). Treatment with MRTX1257 very markedly limited tumour growth compared to vehicle-treated mice, although significant tumour regression was not observed (Supplementary Fig. 3), a total of 12 regions of interest (ROIs) ranging from 1–9 mm2 were selected for downstream analysis with IMC; six tumours for each treatment group and where possible including adjacent normal tissue.Maldegem Erotic Massage
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